GLP-1 & weight-loss clinical trials in Missouri
12 GLP-1 or weight-loss trials are recruiting in Missouri as of July 14, 2026, with sites in Chesterfield, City of Saint Peters, Columbia, Kansas City, Springfield and more. Many studies reimburse time and travel — the amount is set by each study and confirmed when you contact the team.
- A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
Phase 2 · ~1481 participants · NCT06143956
Studied intervention: Tirzepatide
Missouri sites: City of Saint Peters, Springfield
- Impact GLP-1 Agonists Following Bariatric
Phase 4 · ~150 participants · NCT06132477
Studied intervention: GLP-1 receptor agonist
Missouri site: Columbia
- A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease
Phase 2 · ~465 participants · NCT06717698
Studied intervention: Semaglutide
Missouri site: Kansas City
- A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity
Phase 2 · ~230 participants · NCT07639021
Studied intervention: Semaglutide, Semaglutide placebo
Missouri site: City of Saint Peters
- A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Phase 3 · ~800 participants · NCT07153471
Studied intervention: Orforglipron
Missouri sites: City of Saint Peters, Kansas City
- A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
Phase 3 · ~125 participants · NCT06672549
Studied intervention: Orforglipron
Missouri site: St Louis
- Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity
N/A · ~40 participants · NCT07091500
Studied intervention: Semaglutide
Missouri site: St Louis
- A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
Phase 3 · ~2500 participants · NCT07564414
Studied intervention: Semaglutide
Missouri sites: Chesterfield, St Louis
- A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
Phase 3 · ~150 participants · NCT06672939
Studied intervention: Orforglipron
Missouri site: St Louis
- Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
Phase 3 · ~290 participants · NCT06937099
Studied intervention: Tirzepatide
Missouri site: St Louis
- A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
Phase 3 · ~586 participants · NCT07035093
Studied intervention: Retatrutide
Missouri site: Springfield
- Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
Phase 3 · ~350 participants · NCT06937086
Studied intervention: Tirzepatide
Missouri site: St Louis
What joining a GLP-1 trial in Missouri actually involves
Every study above is registered on ClinicalTrials.gov, the US National Library of Medicine's public registry, and each link goes straight to that record — the one place the eligibility criteria, the schedule of visits and the contact details are kept current. A recruiting listing means the study is actively enrolling; it does not mean you are eligible until the study team screens you.
- Reimbursement is not the same as payment. Many studies cover time and travel, but the amount is set per study and confirmed by the team — treat any specific figure you see elsewhere as unverified until they tell you.
- You may receive a placebo. Most of these are randomized, so joining is not a guaranteed route to the active drug. That is worth weighing if your goal is treatment rather than contributing to the evidence.
- Trial participation is free to join and separate from a prescription. If your aim is to start a GLP-1 now, compare the cash-pay routes instead — trials are a different path with a different purpose.
Source: ClinicalTrials.gov (US National Library of Medicine), public-domain data, snapshot July 14, 2026. This is not medical advice or a recruitment service — confirm status, eligibility, and compensation on each linked ClinicalTrials.gov record and discuss any trial with your clinician.