3-way comparison
Ozempic vs Rybelsus vs Saxenda
Side-by-side breakdown — efficacy, cost, regulatory status, and who each option fits best.
Side-by-side comparison
| Attribute | Ozempic | Rybelsus | Saxenda |
|---|---|---|---|
| Generic name | semaglutide | semaglutide | liraglutide |
| Drug class | — | — | — |
| Regulatory status | FDA approved | FDA approved | FDA approved |
| Manufacturer | Novo Nordisk | Novo Nordisk | Novo Nordisk |
| Avg retail price | $968/mo | $968/mo | $1349/mo |
| Without insurance | $968–$1100/mo | $850–$1100/mo | $1100–$1500/mo |
| Savings card max | $25/mo | $10/mo | $25/mo |
| Shortage status | not_listed | resolved | resolved |
FAQ
What is the difference between Ozempic, Rybelsus, and Saxenda?
Ozempic (semaglutide), Rybelsus (semaglutide), and Saxenda (liraglutide) are GLP-1 medications used for weight management or type 2 diabetes. Key differences: Ozempic is FDA-approved, Rybelsus is FDA-approved, Saxenda is FDA-approved.
Which is most effective for weight loss: Ozempic, Rybelsus, or Saxenda?
Effectiveness varies by individual. In clinical trials, tirzepatide-based drugs (Mounjaro, Zepbound) produced ~22% average body-weight loss vs ~15% for semaglutide-based (Ozempic, Wegovy). Discuss with your prescriber.
Which is cheapest?
Cash retail price: Ozempic $968/mo · Rybelsus $968/mo · Saxenda $1349/mo. Compounded versions through telehealth typically run 60-80% less.
See per-drug deep dives: Ozempic review · Rybelsus review · Saxenda review
2-way head-to-heads
Drill down into any pair from the three above for deeper side-by-side analysis.
Already on one? Switching guides
Dose conversion + transition timeline for each directional switch.