3-way comparison
Wegovy vs Zepbound vs Ozempic
Side-by-side breakdown — efficacy, cost, regulatory status, and who each option fits best.
Side-by-side comparison
| Attribute | Wegovy | Zepbound | Ozempic |
|---|---|---|---|
| Generic name | semaglutide | tirzepatide | semaglutide |
| Drug class | — | — | — |
| Regulatory status | FDA approved | FDA approved | FDA approved |
| Manufacturer | Novo Nordisk | Eli Lilly | Novo Nordisk |
| Avg retail price | $1349/mo | $1086/mo | $968/mo |
| Without insurance | $1349–$1500/mo | $349–$1086/mo | $968–$1100/mo |
| Savings card max | $0/mo | $25/mo | $25/mo |
| Shortage status | not_listed | not_listed | not_listed |
FAQ
What is the difference between Wegovy, Zepbound, and Ozempic?
Wegovy (semaglutide), Zepbound (tirzepatide), and Ozempic (semaglutide) are GLP-1 medications used for weight management or type 2 diabetes. Key differences: Wegovy is FDA-approved, Zepbound is FDA-approved, Ozempic is FDA-approved.
Which is most effective for weight loss: Wegovy, Zepbound, or Ozempic?
Effectiveness varies by individual. In clinical trials, tirzepatide-based drugs (Mounjaro, Zepbound) produced ~22% average body-weight loss vs ~15% for semaglutide-based (Ozempic, Wegovy). Discuss with your prescriber.
Which is cheapest?
Cash retail price: Ozempic $968/mo · Zepbound $1086/mo · Wegovy $1349/mo. Compounded versions through telehealth typically run 60-80% less.
See per-drug deep dives: Wegovy review · Zepbound review · Ozempic review
2-way head-to-heads
Drill down into any pair from the three above for deeper side-by-side analysis.
Already on one? Switching guides
Dose conversion + transition timeline for each directional switch.