GLP-1 interactions · Mental health
GLP-1 medications with antidepressants & mental-health medications
Most GLP-1 medications can be used with antidepressants & mental-health medications, but 0 of 46 reviewed pairs carry a major or moderate interaction that needs monitoring or dose adjustment. The most common consideration is additive effect or altered absorption — always confirm your specific combination with your prescriber or pharmacist.
Reviewed pairs (46)
- Rybelsus + Duloxetine (Cymbalta)SNRI (mental health/pain)Minor
- Rybelsus + Escitalopram (Lexapro)SSRI (mental health)Minor
- Rybelsus + Fluoxetine (Prozac)SSRI (mental health)Minor
- Rybelsus + Sertraline (Zoloft)SSRI (mental health)Minor
- Mounjaro + Alprazolam (Xanax)Benzodiazepine (anti-anxiety)No known interaction
- Mounjaro + Bupropion (Wellbutrin)Atypical antidepressantNo known interaction
- Mounjaro + Duloxetine (Cymbalta)SNRI (mental health/pain)No known interaction
- Mounjaro + Escitalopram (Lexapro)SSRI (mental health)No known interaction
- Mounjaro + Fluoxetine (Prozac)SSRI (mental health)No known interaction
- Mounjaro + Sertraline (Zoloft)SSRI (mental health)No known interaction
- Mounjaro + Trazodone (Desyrel)Sedative antidepressant (sleep)No known interaction
- Mounjaro + Zolpidem (Ambien)Sedative-hypnotic (sleep)No known interaction
- Ozempic + Alprazolam (Xanax)Benzodiazepine (anti-anxiety)No known interaction
- Ozempic + Bupropion (Wellbutrin)Atypical antidepressantNo known interaction
- Ozempic + Duloxetine (Cymbalta)SNRI (mental health/pain)No known interaction
- Ozempic + Escitalopram (Lexapro)SSRI (mental health)No known interaction
- Ozempic + Fluoxetine (Prozac)SSRI (mental health)No known interaction
- Ozempic + Mirtazapine (Remeron)Atypical antidepressantNo known interaction
- Ozempic + Sertraline (Zoloft)SSRI (mental health)No known interaction
- Ozempic + Trazodone (Desyrel)Sedative antidepressant (sleep)No known interaction
- Ozempic + Zolpidem (Ambien)Sedative-hypnotic (sleep)No known interaction
- Rybelsus + Alprazolam (Xanax)Benzodiazepine (anti-anxiety)No known interaction
- Rybelsus + Bupropion (Wellbutrin)Atypical antidepressantNo known interaction
- Rybelsus + Mirtazapine (Remeron)Atypical antidepressantNo known interaction
- Rybelsus + Trazodone (Desyrel)Sedative antidepressant (sleep)No known interaction
- Rybelsus + Zolpidem (Ambien)Sedative-hypnotic (sleep)No known interaction
- Saxenda + Alprazolam (Xanax)Benzodiazepine (anti-anxiety)No known interaction
- Saxenda + Trazodone (Desyrel)Sedative antidepressant (sleep)No known interaction
- Saxenda + Zolpidem (Ambien)Sedative-hypnotic (sleep)No known interaction
- Wegovy + Alprazolam (Xanax)Benzodiazepine (anti-anxiety)No known interaction
- Wegovy + Bupropion (Wellbutrin)Atypical antidepressantNo known interaction
- Wegovy + Duloxetine (Cymbalta)SNRI (mental health/pain)No known interaction
- Wegovy + Escitalopram (Lexapro)SSRI (mental health)No known interaction
- Wegovy + Fluoxetine (Prozac)SSRI (mental health)No known interaction
- Wegovy + Mirtazapine (Remeron)Atypical antidepressantNo known interaction
- Wegovy + Sertraline (Zoloft)SSRI (mental health)No known interaction
- Wegovy + Trazodone (Desyrel)Sedative antidepressant (sleep)No known interaction
- Wegovy + Zolpidem (Ambien)Sedative-hypnotic (sleep)No known interaction
- Zepbound + Alprazolam (Xanax)Benzodiazepine (anti-anxiety)No known interaction
- Zepbound + Bupropion (Wellbutrin)Atypical antidepressantNo known interaction
- Zepbound + Duloxetine (Cymbalta)SNRI (mental health/pain)No known interaction
- Zepbound + Escitalopram (Lexapro)SSRI (mental health)No known interaction
- Zepbound + Fluoxetine (Prozac)SSRI (mental health)No known interaction
- Zepbound + Sertraline (Zoloft)SSRI (mental health)No known interaction
- Zepbound + Trazodone (Desyrel)Sedative antidepressant (sleep)No known interaction
- Zepbound + Zolpidem (Ambien)Sedative-hypnotic (sleep)No known interaction
Common questions
Can you take GLP-1 medications with antidepressants & mental-health medications?
Most GLP-1 medications can be used with antidepressants & mental-health medications, but 0 of 46 reviewed pairs carry a major or moderate interaction that needs monitoring or dose adjustment. The most common consideration is additive effect or altered absorption — always confirm your specific combination with your prescriber or pharmacist.
Which GLP-1 + mental health combinations need the most caution?
No major interactions are flagged in this class; 0 moderate pair(s) warrant monitoring. See the list below.
Educational summary of FDA prescribing information — not medical advice and not a complete interaction screen. Always confirm any medication combination with your prescriber or pharmacist.