Quick answer
Body mass index is weight (kg) divided by height (m) squared. FDA labels for Wegovy and Zepbound require BMI 30+ for obesity, or 27+ with at least one weight-related comorbidity.
Full definition
BMI categorizes adults as underweight (<18.5), normal (18.5-24.9), overweight (25-29.9), obesity class I (30-34.9), class II (35-39.9), or class III (40+). FDA labels for chronic-weight-management GLP-1s (Wegovy, Zepbound, Saxenda) require BMI 30+ OR BMI 27+ with at least one weight-related comorbidity (hypertension, T2D, dyslipidemia, OSA, cardiovascular disease). BMI has known limitations — it does not differentiate fat from lean mass and misclassifies muscular individuals. Modern obesity medicine increasingly supplements BMI with waist circumference, body composition, and metabolic markers.
Deep dive
BMI (Body Mass Index): complete reference
Body Mass Index (BMI) is a numeric value calculated from a person’s weight and height (kg/m² in metric, or lb × 703 / in² in US units) used as a screening tool for weight categories. Classification: underweight (<18.5), normal (18.5-24.9), overweight (25-29.9), obesity class I (30-34.9), class II (35-39.9), and class III (≥40, formerly “morbid obesity”). BMI is the standard threshold for many GLP-1 indications: Wegovy and Zepbound are FDA-approved for adults with BMI ≥30, or BMI ≥27 with a weight-related comorbidity (T2D, hypertension, dyslipidemia, OSA, CVD). BMI has well-documented limitations — it does not distinguish muscle from fat, underestimates body fat in older adults, and overestimates it in athletes with high muscle mass — so clinical evaluation should include additional measures (waist circumference, body composition, comorbidities) for accurate risk stratification. Despite limitations, BMI remains the most widely used tool because it is simple, requires no equipment, and has decades of population-level outcome data.
- In practice
- A person who is 5'9" (175cm) and weighs 200 lbs (91kg) has BMI 29.5 (overweight); at 210 lbs (95kg) BMI is 31 (obesity class I) — crossing the threshold for FDA-approved weight-loss medication eligibility.
- Clinical context
- Insurance prior-auth decisions and FDA labels both rely on BMI thresholds. Clinicians document BMI at each visit for both medication eligibility and risk monitoring.
Medications
BMI (Body Mass Index) is most directly relevant to the following GLP-1 medications:
Related terms
- Body Composition — The proportion of fat mass, lean mass (muscle), bone, and water in the body. GLP-1-induced weight lo…
- Lean Mass — Body weight excluding fat — primarily skeletal muscle, organs, bone, and water. Preserving lean mass…
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GLP1Zoom glossary is educational reference. Definitions are summary interpretations of clinical sources and not a substitute for prescribing-information detail. Full disclaimer.
References
Glucagon-Like Peptide-1 Receptor Agonists: Mechanisms и Clinical Use (Drucker, Cell Metabolism)(2018)
Tirzepatide GIP/GLP-1 Dual Agonism: Mechanism Review (Lancet Diabetes & Endocrinology)(2021)
GLP-1 Effects on Gastric Emptying: Pharmacology Review (American J Physiology)(2020)
Endocrine Society Clinical Practice Guideline: Pharmacological Management of Obesity(2015)
STEP-1 trial: Once-Weekly Semaglutide in Adults with Overweight or Obesity (Wilding et al., NEJM)(2021)
SURMOUNT-1 trial: Tirzepatide Once Weekly для Treatment of Obesity (Jastreboff et al., NEJM)(2022)
SUSTAIN-6 trial: Semaglutide and Cardiovascular Outcomes (Marso et al., NEJM)(2016)
SURPASS-2 trial: Tirzepatide vs Semaglutide в Type 2 Diabetes (Frias et al., NEJM)(2021)
LEADER trial: Liraglutide and Cardiovascular Outcomes в T2D (Marso et al., NEJM)(2016)