GLP-1 interactions · GI / acid
GLP-1 medications with GI & acid medications
Most GLP-1 medications can be used with GI & acid medications, but 2 of 23 reviewed pairs carry a major or moderate interaction that needs monitoring or dose adjustment. The most common consideration is additive effect or altered absorption — always confirm your specific combination with your prescriber or pharmacist.
Reviewed pairs (23)
- Rybelsus + Omeprazole (Prilosec)PPI (gastrointestinal)Moderate
- Rybelsus + Pantoprazole (Protonix)PPI (gastrointestinal)Moderate
- Mounjaro + Omeprazole (Prilosec)PPI (gastrointestinal)Minor
- Mounjaro + Pantoprazole (Protonix)PPI (gastrointestinal)Minor
- Ozempic + Omeprazole (Prilosec)PPI (gastrointestinal)Minor
- Ozempic + Ondansetron (Zofran)Antiemetic (gastrointestinal)Minor
- Ozempic + Pantoprazole (Protonix)PPI (gastrointestinal)Minor
- Saxenda + Omeprazole (Prilosec)PPI (gastrointestinal)Minor
- Saxenda + Pantoprazole (Protonix)PPI (gastrointestinal)Minor
- Wegovy + Omeprazole (Prilosec)PPI (gastrointestinal)Minor
- Wegovy + Ondansetron (Zofran)Antiemetic (gastrointestinal)Minor
- Wegovy + Pantoprazole (Protonix)PPI (gastrointestinal)Minor
- Zepbound + Omeprazole (Prilosec)PPI (gastrointestinal)Minor
- Zepbound + Pantoprazole (Protonix)PPI (gastrointestinal)Minor
- Mounjaro + Famotidine (Pepcid)H2 blocker (gastrointestinal)No known interaction
- Mounjaro + Ondansetron (Zofran)Antiemetic (gastrointestinal)No known interaction
- Ozempic + Famotidine (Pepcid)H2 blocker (gastrointestinal)No known interaction
- Rybelsus + Ondansetron (Zofran)Antiemetic (gastrointestinal)No known interaction
- Saxenda + Famotidine (Pepcid)H2 blocker (gastrointestinal)No known interaction
- Saxenda + Ondansetron (Zofran)Antiemetic (gastrointestinal)No known interaction
- Wegovy + Famotidine (Pepcid)H2 blocker (gastrointestinal)No known interaction
- Zepbound + Famotidine (Pepcid)H2 blocker (gastrointestinal)No known interaction
- Zepbound + Ondansetron (Zofran)Antiemetic (gastrointestinal)No known interaction
Common questions
Can you take GLP-1 medications with GI & acid medications?
Most GLP-1 medications can be used with GI & acid medications, but 2 of 23 reviewed pairs carry a major or moderate interaction that needs monitoring or dose adjustment. The most common consideration is additive effect or altered absorption — always confirm your specific combination with your prescriber or pharmacist.
Which GLP-1 + gi / acid combinations need the most caution?
No major interactions are flagged in this class; 2 moderate pair(s) warrant monitoring. See the list below.
Educational summary of FDA prescribing information — not medical advice and not a complete interaction screen. Always confirm any medication combination with your prescriber or pharmacist.