In STEP-1, Wegovy (brand semaglutide) produced about 14.9% average body-weight loss over 68 weeks. Compounded versions were not in that trial, and the FDA does not review compounded drugs for potency, purity, or effectiveness — do not expect the same result. That is a trial average; individual results vary widely and depend on staying on treatment.
What Compounded Semaglutide is approved for
Nothing: Compounded Semaglutide is not FDA-approved, so no label lists approved uses. The brand products with the same active ingredient carry their own.
Compounded Semaglutide weight-loss results
Wegovy (brand semaglutide) produced 14.9% mean body-weight reduction in the STEP-1 pivotal trial at 68 weeks. Compounded versions were not in that trial, and the FDA does not review compounded drugs for potency, purity, or effectiveness — do not expect the same result.
How effective is Wegovy (brand semaglutide)?
Mean body-weight change at 68 weeks in the STEP-1 trial. Source: FDA prescribing information.
Vs placebo
+12.5 pts
Strong active-treatment signal
Vs GLP-1 class ceiling
66% of ceiling
Above-average GLP-1
Individual results vary. Trial participants also received lifestyle counseling. Full disclaimer.
Expected weight-loss curve
Mean body-weight change across 68 weeks on Wegovy (brand semaglutide) from the STEP-1 trial. Curve smoothed from published endpoints; individual results vary significantly.
Trial participants also received lifestyle counseling. Real-world results depend on dose adherence, side-effect tolerance, and lifestyle factors.
Why results vary, what happens after stopping, and how GLP-1 medicines compare with other approaches are covered once for the whole class in GLP-1 weight-loss results. Side effects that make people stop early are on the Compounded Semaglutide side effects page.
FAQ about Compounded Semaglutide for weight loss
Is Compounded Semaglutide FDA-approved for weight loss?
No. Compounded Semaglutide is a compounded product and is not FDA-approved for any use.
Educational only, not medical advice. Full medical disclaimer.