In SURMOUNT-1, Zepbound produced about 22.5% average body-weight loss over 72 weeks. That is a trial average; individual results vary widely and depend on staying on treatment.
What Zepbound is approved for
Weight reduction and long-term maintenance in adults with obesity, or with overweight and a weight-related condition, and moderate to severe obstructive sleep apnea in adults with obesity.
Zepbound weight-loss results
Zepbound produced 22.5% mean body-weight reduction in the SURMOUNT-1 pivotal trial at 72 weeks. That figure is a mean: within the same trial some people lost far more and a minority lost little, so read it as the middle of a wide spread rather than a target.
How effective is Zepbound?
Mean body-weight change at 72 weeks in the SURMOUNT-1 trial. Source: FDA prescribing information.
Vs placebo
+20.1 pts
Strong active-treatment signal
Vs GLP-1 class ceiling
100% of ceiling
Class-leading efficacy
Individual results vary. Trial participants also received lifestyle counseling. Full disclaimer.
Expected weight-loss curve
Mean body-weight change across 72 weeks on Zepbound from the SURMOUNT-1 trial. Curve smoothed from published endpoints; individual results vary significantly.
Trial participants also received lifestyle counseling. Real-world results depend on dose adherence, side-effect tolerance, and lifestyle factors.
Why results vary, what happens after stopping, and how GLP-1 medicines compare with other approaches are covered once for the whole class in GLP-1 weight-loss results. Side effects that make people stop early are on the Zepbound side effects page.
FAQ about Zepbound for weight loss
Is Zepbound FDA-approved for weight loss?
Yes. The label's approved uses: weight reduction and long-term maintenance in adults with obesity, or with overweight and a weight-related condition, and moderate to severe obstructive sleep apnea in adults with obesity.
For what those numbers look like in practice — the share of people who reached each level, the month-by-month timeline, and what happens when you stop — see Zepbound before and after: what the data shows.
Educational only, not medical advice. Full medical disclaimer.