The Zepbound label reports hair loss in about 5% of patients versus 1% on placebo, in the adverse-reaction table (Section 6.1) — not as a warning. No Zepbound trial patient stopped treatment because of hair loss. The shedding some people notice on GLP-1 medicines is usually telogen effluvium, temporary shedding that follows rapid weight loss rather than damage to hair follicles. It typically starts two to four months after the fastest weight loss, and the American Academy of Dermatology puts recovery at six to nine months once the trigger settles.
What the Zepbound label says
The Zepbound label reports hair loss in about 5% of patients versus 1% on placebo, in the adverse-reaction table (Section 6.1) — not as a warning. No Zepbound trial patient stopped treatment because of hair loss.
By sex: 7.1% of women versus 0.5% of men — the widest sex gap of any drug in the class.
Unlike Wegovy, Zepbound shows no dose-response: 5% at 5 mg, 4% at 10 mg, 5% at 15 mg. So the honest picture is mixed — the class as a whole tracks weight loss, but the per-dose numbers within a single drug do not always line up, and no study has separated dose from the weight lost at that dose.
Hair loss is listed as an adverse reaction, never as a boxed or Section 5 warning, for any drug in this class.
Why it happens, when it stops, why some people say it never grew back, what helps (and why biotin can interfere with lab tests), and when shedding points to something else are covered once for all GLP-1 medicines: GLP-1 hair loss and what helps with GLP-1 hair loss.
Common questions
Does Zepbound cause hair loss?
The Zepbound label reports hair loss in about 5% of patients versus 1% on placebo, in the adverse-reaction table (Section 6.1) — not as a warning. No Zepbound trial patient stopped treatment because of hair loss.
Does biotin help hair loss on Zepbound?
Evidence does not support biotin unless you are genuinely deficient, which is rare. The FDA also warns that biotin interferes with lab tests, including troponin, where it can produce a falsely low result and mask a heart attack. Test before supplementing.