In SCALE, Saxenda averaged about 1.5% body-weight loss by week 4, 4.5% by week 12 and about 8% by week 56. The dose is raised in steps, so the effect builds over months; individual results vary widely.
When Saxenda reaches its full dose
- Week 1: 0.6 mg/day
- Week 2: 1.2 mg/day
- Week 3: 1.8 mg/day
- Week 4: 2.4 mg/day
- Week 5+: 3 mg/day — Maintenance dose for adults; the lower doses are for titration only.
Expected weight-loss curve
Mean body-weight change across 56 weeks on Saxenda from the SCALE trial. Curve smoothed from published endpoints; individual results vary significantly.
Trial participants also received lifestyle counseling. Real-world results depend on dose adherence, side-effect tolerance, and lifestyle factors.
When to reassess
The label says to check weight 16 weeks after starting and to stop Saxenda if you have not lost at least 4% of your starting weight, because further loss is then unlikely.
Why GLP-1 medicines work gradually, and what the first weeks usually feel like, is covered once for the whole class in how long GLP-1 medications take to work.
Common questions
How long does Saxenda stay in the body?
Saxenda has a half-life of about 13 hours and is taken once DAILY, not weekly.
When should I talk to my prescriber if Saxenda isn't working?
The label says to check weight 16 weeks after starting and to stop Saxenda if you have not lost at least 4% of your starting weight, because further loss is then unlikely.