Trulicity is a GLP-1 receptor agonist medication containing dulaglutide, made by Eli Lilly. It mimics the GLP-1 gut hormone to reduce appetite, slow digestion, and improve blood-sugar control, which is why it is used for weight management and/or type 2 diabetes — producing an average of about 12% body-weight loss in the class average trial.
| Active ingredient | dulaglutide |
|---|---|
| Drug class | GLP-1 receptor agonist |
| Manufacturer | Eli Lilly |
| Regulatory status | FDA-approved prescription medication |
| How it’s taken | Subcutaneous injection |
| Avg. weight loss (trial) | ~12% at 68 wks (class average) |
What is Trulicity used for?
Trulicityis prescribed for chronic weight management and/or type 2 diabetes, depending on the specific brand and its FDA-approved indication. In the GLP-1 class, some products are labeled for diabetes (improving blood-sugar control) and some for weight management (in adults with obesity, or overweight plus a weight-related condition such as high blood pressure, sleep apnea, or cardiovascular disease). Always follow the indication and eligibility on the FDA label and your prescriber's guidance. See the clinical evidence on our Trulicity for weight loss page.
How does Trulicity work?
Trulicity mimics glucagon-like peptide-1 (GLP-1), a hormone your gut releases after eating. By activating GLP-1 receptors, it slows how fast your stomach empties so you feel full longer, dampens appetite and “food noise” in the brain, and helps regulate insulin and blood sugar. The net effect is reduced calorie intake and, for many people, substantial weight loss. For the full mechanism, see how Trulicity works.
Who makes Trulicity?
Trulicity is manufactured by Eli Lilly. The active ingredient, dulaglutide, is a synthetic peptide engineered to resist the rapid breakdown that natural GLP-1 undergoes, so a single dose keeps working for days.
Is Trulicity the same as other GLP-1 drugs?
Several GLP-1 medications share an active ingredient but differ by brand name, dose, and labeled use. dulaglutide is the active ingredient in Trulicity; the same molecule may be sold under other brand names for different indications. The leading GLP-1 molecules are semaglutide, tirzepatide, and liraglutide. To see how Trulicity stacks up on weight loss, side effects, and cost, use our side-by-side comparison tool or read semaglutide vs tirzepatide.
Trulicity: brand vs. compounded
You may see Trulicity (or its active ingredient dulaglutide) offered as the FDA-approved brand or as a lower-cost compounded version through telehealth. Compounded versions contain the same active ingredient but are not FDA-approved finished products, and quality can vary by pharmacy. Brand products carry full FDA review. We explain the price difference on our Trulicity cost guide and the trade-offs in our medical disclaimer.
How much does Trulicity cost?
Without insurance, brand GLP-1s list at roughly $1,000–$1,350/month, though manufacturer cash programs and compounded versions can cut that substantially. For a personalized estimate and live partner pricing, see the Trulicity cost and savings pages, or find the cheapest GLP-1 options.
Questions to ask your doctor about Trulicity
Check the ones you want to raise and print this to bring to your appointment — a short visit goes further when you walk in prepared.
Am I a candidate?
- Given my BMI, weight history, and other conditions, am I a good candidate for Trulicity?
- Do any of my conditions or medications make Trulicity a bad fit for me?
- Do I have any personal or family history (thyroid C-cell cancer / MEN 2, pancreatitis) that rules it out?
Starting & dosing
- What is my exact titration schedule — which dose, and when does it step up?
- What should I do if I miss a dose?
- How soon should I expect to see results, and what is a realistic target?
- How and where do I inject it, and how do I store it?
Side effects & safety
- Which side effects are normal, and which ones mean I should call you or seek care?
- What can I do to manage nausea and other GI side effects?
- Are any of my current medications affected (for example, does it change how my birth control or other pills work)?
- When would you consider pausing or stopping it?
Cost & coverage
- Is Trulicity covered by my insurance, and will it need prior authorization?
- Is there a manufacturer savings card or patient-assistance program I qualify for?
- If it isn't covered, what are the cheaper options you'd recommend?
- Is a compounded version appropriate for me, and what are the trade-offs versus the FDA-approved brand?
See also: the questions your doctor will ask YOU — a printable prep worksheet.
These are conversation prompts to help you prepare, not medical advice — your prescriber gives the answers based on your health.
Frequently asked questions about Trulicity
What is Trulicity used for?
Trulicity is used for chronic weight management and/or type 2 diabetes, depending on its specific FDA-approved indication; some products in this class are also FDA-approved for additional uses (for example, cardiovascular risk reduction or obstructive sleep apnea). Medications in this class work mainly through the GLP-1 pathway — and, for tirzepatide, also the GIP pathway — which can help reduce appetite and support blood-sugar control. Compounded versions are not FDA-approved and are not approved for any specific indication. This is general information, not medical advice.
Is Trulicity a GLP-1?
Yes. Trulicity is a GLP-1 receptor agonist, the class of medications that mimic the GLP-1 gut hormone.
Is Trulicity FDA-approved?
Yes — Trulicity is an FDA-approved prescription medication. Compounded versions of the same active ingredient are not FDA-approved finished products.
Who makes Trulicity?
Trulicity is made by Eli Lilly.
See also: Trulicity for weight loss · side effects · dosage · cost. Editorial summary based on FDA prescribing information — not medical advice. Full disclaimer.