Yes — store unopened Trulicity in the refrigerator (36°F–46°F (2°C–8°C) before use). Once you start a pen, it can stay at room temperature: Per product-specific instructions Per product-specific instructions
Storage & timing for Trulicity
Practical handling guidance. Always follow the dispensed label.
Before use
36°F–46°F (2°C–8°C) before use
At room temperature
Per product-specific instructions
After first use
Per product-specific instructions
When to inject
Per prescribing label
If you miss a dose
Refer to product label or contact prescriber
Does Trulicity need to be refrigerated?
Before you open it, yes — keep Trulicity refrigerated at 36°F–46°F (2°C–8°C) before use. Do not freeze it; a pen that has frozen should not be used even after thawing. After first use, most people can keep the pen at room temperature: Per product-specific instructions Track the date you first used it so you know when to discard: Per product-specific instructions
What if Trulicity was left out of the fridge?
An unopened pen left at room temperature is generally still usable within the room-temperature window on the label (per product-specific instructions), but once that window is exceeded — or if it was exposed to heat above the labeled limit or to freezing — it should not be used. If you are unsure how long it sat out or how warm it got, call your pharmacist before injecting; do not guess. Never use a pen that has been frozen.
Traveling with Trulicity
For trips, carry Trulicity in an insulated bag with a cold pack (not directly touching the pen, to avoid freezing) and keep it in your carry-on, never a checked bag or a hot car. At your destination, refrigerate any unopened pens. Airport security allows medically necessary medication and cold packs; a pharmacy label or prescription can smooth the screening.
When to take Trulicity
Per prescribing label If you miss a dose: Refer to product label or contact prescriber
Common questions
Does Trulicity need to be refrigerated?
Unopened Trulicity should be kept in the refrigerator (36–46°F / 2–8°C). Once you start using an injectable pen, it can usually stay at room temperature for a labeled number of days — check your specific product. Rybelsus (oral semaglutide) is the exception: it is stored at room temperature. Never freeze an injectable pen; if it freezes, do not use it.
How long can Trulicity stay out of the fridge?
It depends on the product — the room-temperature window ranges from about 21 to 56 days after first use for the injectables, printed on your label. An unopened pen left out is generally fine within that same window but should be discarded if it exceeds it or was exposed to heat above the labeled limit. If you're unsure how long it sat out, ask your pharmacist before using it.
Can I travel with Trulicity?
Yes. Carry Trulicity in an insulated bag with a cold pack (not touching the pen, to avoid freezing) in your carry-on — never a checked bag or a hot car. Refrigerate unopened pens at your destination. Airport security permits medically necessary medication and cold packs; keeping the pharmacy label or prescription handy helps at screening.
Is Trulicity still good if it was left out overnight?
Often yes, if it stayed within the labeled room-temperature window and didn't get too hot or freeze — but check the number of days your product allows at room temperature and how warm it got. When in doubt, call your pharmacist rather than guessing. Never use a pen that has frozen, even once.